Although athletic trainers cannot prescribe or dispense prescription medications, they should be as aware of their effects as they are of other methods of injury treatment. A comparative pharmacokinetic study of aspirin suppositories. This compound had the medicinal properties of salicylic acid, an extract of willow bark. It has the ability to reduce fever an antipyretic, to reduce pain an analgesic, and to reduce swelling, soreness, and redness an antiinflammatory agent. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. Preparation and recrystallisation of aspirin biology essay. Preparation of aspirin experiment 5 introduction in this experiment you will prepare a sample of aspirin, recrystallize the raw product, and determine the percentage yield of the aspirin based on the limiting reactant. Click on the box in front of preparation of titrate we can see procedure of preparation of titrate aspirin after selecting the volume of aspirin. It is the twostep synthesis of aspirin starting from oil of wintergreen.
Pdf preparation of aspirin and acetaminophen alexander. The discoveries that changed contemporary medicine 179 us physicians health study and the british doctors trial, it has been con cluded that the use of lowdose aspirin is safe and effective in subjects with coronary event risk of at least 1. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic anhydride 2 to produce aspirin 3 and acetic acid 4. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. Aspirin is only found in individuals who have consumed this drug. Sulphuric acid is added and heated for a short period to complete reaction. Once solid dissolved, weigh the watch glass and filter paper, use the filter paper to carry out suction filtration, place crystals on watch glass, weigh the. Nsaids aspirin, ibuprofen, naproxen, or others have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed do not use if you have ever had an allergic reaction to aspirin or any other pain relieverfever reducer. This reaction results in the removal of a hydrogen atom of the hydroxyl group attached to the ring on salicylic acid being replaced by an acetyl group.
Pharmacokinetics and pharmacodynamics of acetylsalicylic acid. The use of aspirin had its origin in the 18th century, when it was found that an extract from the. One of the most consumed drugs production in the us is 10 million kgyear aspirin. It is often used to relieve minor aches and pains, reduce fever and as an antiinflammatory medication. Aspirin insoluble so add sodium citrate surfactant to make it soluble complex, if substance with large particle size crystal we must decrease particle size by using mortar to increase the solubility if we have gum substances we must prepare it in a wide mouth. Pain relief and more chemsumer b ut before you settle into channel surfing, think about that bottle of aspirin or ibuprofen.
E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity. Now, 50 million 5 grain tablets are consumed daily. This clearly qualitatively shows the level of impurity as it is much heavier showing it contains other compounds weighing it down, which it should. Chemistry 51 experiment 11 synthesis and analysis of aspirin. The crystals were vacuum filtered and the flask rinsed with a small amount of water. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. You can compare the quality of the synthesized aspirin with commercial aspirin and salicylic acid. One hour prior to your appointment, please drink 16 to 24 ounces of water. Aspirin is used medically to reduce fever and pain. Aspirin given shortly after a heart attack decreases the risk of death. Biological activity analgesic painkiller antipyretic fever reducer antiinflammatory inhibition of the synthesis of prostaglandins side effects.
Pdf preparation and evaluation of aspirin transdermal. Aspirin and esters lab report shahil shahil keshav lisa. Preparation of aspirin and oil of wintergreen essay example for free newyorkessays database with more than 65000 college essays for studying. Organic chemistry covers a wide range of molecules that all contain hydrogen and carbon. Results and conclusion for aspirin synthesis essay medicine. Mar 19, 2014 the pharmacology of single doses of acetylsalicylic acid asa administered intravenously 250 or 500 mg or orally 100, 300, or 500 mg was evaluated in a randomized, placebocontrolled, crossover study. If it is in preparation for distribution for distributors, the packages are then boxed in larger cardboard boxes. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic anhydride 2.
If aspirin forms in the filtrate in the vacuum flask, transfer the filtrate and aspirin to a beaker, chill in an ice bath, and vacuum filter as before. The risks of these events increase with increasing aspirin dose. Aspirin preparation lab report, lab report buy sample. Ask a doctor before use if stomach bleeding warning applies to you. Aspirin is an orally administered nonsteroidal antiinflammatory agent. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and. Unlike many other formulations, the production of hard aspirin tablets only requires four ingredients. The sharpness of the melting point is useful to measure purity using pure aspirin as a comparison.
Essentially, salicylic acid reacts with acetic anhydride in the presence of the catalyst sulfuric acid. Wash the aspirin crystals on the filter paper with 10 ml of ice water. Pdf which aspirin dose and preparation is best for the. One of the most consumed drugs production in the us is 10 million. The production and manufacture of aspirin essay example. Results and conclusion for aspirin synthesis essay. Preparation of aspirin and oil of wintergreen essay sample. Unlike previous reactions where you assumed a 100% yield, this was an equilibrium reaction which resulted in less than 100% yield. The preparation of acetylsalicylic acid is the result of the acetylation of salicylic acid.
The balanced chemical reaction of the formation of. Pure aspirin would show no color, while salicylic acid or traces of it in impure aspirin will show a purple color. This reaction is the reverse of the synthesis reaction. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. An overview of the physiology and pharmacology of aspirin. These are the sources and citations used to research synthesis of aspirin. Aspirin was patented in 1899 by a chemist named felix hofmann who worked for bayer in germany. As for recrystallisation of aspirin, collected crude product prepared in preparation of aspirin which is impure is dissolved in ethanol and hot distilled water is added to the solution. After eons of prehistory as folk remedy, aspirin emerged in 1899 in one of the worlds first industrial research laboratories. It relieves your pain, reduces the inflammation swelling, and generally makes you feel better. Pdf which aspirin dose and preparation is best for the long. The main metabolite is 2hydroxybenzoic acid salicylic acid. Click pipette out button to pipette out the aspirin. Synthesis of aspirin chemistry bibliographies cite.
It is absorbed mainly in its unionised form in the stomach and upper small intestine. San jose kaiser permanente preoperative instructions. The pharmacodynamics of aspirin aspirin inhibits the action of an enzyme. Hydrocarbons are molecules that contain only hydrogen and carbon. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Is this a viable synthesis for preparing aspirin from phenol in a school lab. Chem1020 mctc revised 42320 page 1 of 8 preparation of aspirin objectives. Preparation, purification and analysis of aspirin acetylsalicylic acid synthesis. Pdf preparation and evaluation of aspirin transdermal patch. Hello, this is location name merge calling to confirm an appointment for patient first name merge on daydate merge. From experience to design the science behind aspirin.
Maintain the vacuum to dry the crystals as best possible. Shahil keshav lisa nguyen hunter shepard november 9, 2011 preparation of aspirin and some. Nov 21, 2014 final recrystallization of crude aspirin o coh o cch3 o unreacted salicylic acid recytal. Synthesis and recrystallization of aspirin lab report. The rinsing water was poured through crude aspirin crystals then transferred to a small beaker to await the subsequent experiment. Aspirin is a very effective painkiller and fever reducer, but it causes sideeffectsin some people. The bottles are then packaged in separate cardboard boxes, depending on the manufacturer. Earlier this semester you synthesized aspirin from salicylic acid. The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. Which aspirin dose and preparation is best for the longterm prevention of cardiovascular disease and cancer.
Theory aspirin, acetylsalicylic acid, was first synthesized in 1893 by felix hofmann, a chemist for the german firm of bayer. Pure aspirin has a narrow temperature range during which it changes from a solid to a liquid. The pharmacology of single doses of acetylsalicylic acid asa administered intravenously 250 or 500 mg or orally 100, 300, or 500 mg was evaluated in a randomized, placebocontrolled, crossover study. Review article the mechanism of action of aspirin j.
The balanced chemical reaction of the formation of aspirin. View notes aspirin and esters lab report shahil from ch 116 at university of alabama, birmingham. Preparation of acetylsalicylic acid aspirin background one of the most widely used nonprescription drugs is aspirin. The maximum allowable amount of free salicylic acid in an aspirin sample is 0. E29 preparation of aspirin acetylsalicylic acid and thin. This bibliography was generated on cite this for me on monday, august 24, 2015. The synthesised crude aspirin also shows only one spot but this is very far away from the pure aspirin rf, although it could consist of multiple components close in mass so they merge into one spot.
This is not surprising when one considers the medicinal applications for aspirin. To determine the purity of the aspirin or acetaminophen. An overview of the physiology and pharmacology of aspirin and. Synthesis of aspirin chemistry bibliographies cite this. In the united states, more than 15,000 pounds are sold each year. Add one drop of 1% iron iii chloride to separate test tubes containing a few crystals of each substance. Pharmacokinetics and pharmacodynamics of acetylsalicylic. If not, then look for one of aspirins many cousins, pain killers that, despite their long and widespread usages, never cease to make headline news.
An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. If you take aspirin or aspirin containing products such as ascriptin, bayer, excedrin, bufferin, easprin and ecotrin, any other blood thinners plavix, coumadin, etc. It is a derivative of salicylic acid which is also an. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. It results from the elimination of a molecule of water from two molecules of acetic acid see fig.
The skills by the end of the experiment you should be able to. Synthesis of aspirin synthesis purification characterization aspirin. The production and manufacture of aspirin aspirin is one of the most consumed painkillers created up to this date due to its reliability and low expense. In this article, i present an overview of the actions and effects of aspirin and nonsteroidal antiinflammatory drugs nsaids. Experiment 11 synthesis and analysis of aspirin introduction aspirin is most widely sold overthecounter drug. This agent exhibits analgesic, antipyretic, and anticoagulant properties. Though aspirin is much less irritating than plain salicylic acid, it causes stomach upset in a very small percentage of people. Dissolve a few crystals of aspirin into 5 ml of water inside a test tube 14. When a tablet of aspirin is done, there is often a line put in the center to the tablet can be broken into two parts with ease. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the.